Small particle compositions for intranasal drug delivery
US5707644A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 20, 1994 |
| Grant date | Jan 13, 1998 |
| Priority date | — |
| Expiry date | Dec 20, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A drug delivery composition for intranasal delivery comprises a plurality of bioadhesive microspheres and active drug associated with each microsphere, at least 90 wt % of the microspheres having a diameter in the range 0.1 .mu.m to 10 .mu.m. The microspheres may be of starch, gelatin, dextran, collagen or albumin. Suitable drags include peptides, such as insulin, and antigenic vaccine ingredients. The composition may additionally comprise an absorption enhancer. The microspheres are administered m the nasal cavity by a means such that the product of the square of the microsphere diameter and the flow rate is greater than 2000 .mu.m.sup.2.liters/min.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.