Method of diagnosing renal tissue damage or disease
US5707810A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 6, 1996 |
| Grant date | Jan 13, 1998 |
| Priority date | — |
| Expiry date | May 6, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In one aspect, the present invention provides a method of diagnosing renal tissue damage or disease by measuring endogenous expression of OP-1 by renal tissue of a mammal (e.g., a human) in which a depression of endogenous expression relative to undamaged or undiseased mammalian renal tissue indicates a diagnosis that the mammal is afflicted with renal tissue damage or disease. Also disclosed are methods of diagnosing renal tissue damage or disease in a mammal. The methods involve detecting and/or measuring the expression of the OP-1 (BMP-7) gene or protein in the mammal. Depression of OP-1 expression may be used to diagnose renal tissue damage or disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.