Multifunctional RNA having self-processing activity, the preparation thereof and the use thereof

US5707840A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hubert Mullner · Kelkheim, DE
• Eugen Uhlmann · Königstein, DE
• Peter Eckes · Kelkheim, DE
• Rudolf Schneider · Niedernhausen, DE
• Bernadus Uijtewaal

Key dates

• Filing date: Sep 29, 1994
• Grant date: Jan 13, 1998
• Expiry date: Sep 29, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/121
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A multifunctional RNA having self-processing activity, the preparation thereof and the use thereof. Host cells can be transformed so that they express ribozyme RNA and antisense RNA which are connected with each other via a spacer. The RNA molecules can, for example, be complementary to a certain viral RNA. Plants which have been transformed with genes coding for RNA of this type show a significantly improved resistance to viruses.