DNA oligomers for inhibition of HIV by decreasing ribosomal frameshifting
US5707866A · kind A · utility
2Cited by
0References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 21, 1996 |
| Grant date | Jan 13, 1998 |
| Priority date | — |
| Expiry date | May 21, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/322
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the use of antisense DNA oligomers to decrease the occurrence of ribosomal frameshifting required for the production of HIV enzymatic proteins when translating HIV messenger RNA, which should interfere with the production of virions and disrupt HIV life cycle. The antisense DNA oligomers are complementary to regions of the RNA of the small ribosomal subunit of mammalian cells, which are involved in the control of translation fidelity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.