Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them

US5708034A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinz-Werner Kleemann · Bischofsheim, DE
• Joachim Brendel · Bad Vilbel, DE
• Jan-Robert Schwark · Frankfurt am Main, DE
• Andreas Weichert · Egelsbach, DE
• Hans-Jochen Lang · Hofheim, DE
• Udo Albus · Florstadt, DE
• Wolfgang Scholz · Beverly, US

Key dates

• Filing date: Oct 31, 1996
• Grant date: Jan 13, 1998
• Expiry date: Oct 31, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them Sulfonimidamides of the formula I ##STR1## in which at least one of the three substituents R(1), R(2) and R(3) is a benzoylguanidine, and in which the other substituents have the meanings indicated in the claims, are outstandingly suitable as medicaments having action on the cardiovascular system; that is as antiarrhythmic pharmaceuticals having a cardioprotective component as well as for treating ischemically induced damage; also in operative interventions, such as organ transplantation.