Thioether conjugates
US5708146A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 6, 1995 |
| Grant date | Jan 13, 1998 |
| Priority date | — |
| Expiry date | Jun 6, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are drug/ligand compounds of Formula (I): ##STR1## (I) in which PA1 D is a drug moiety; PA1 n is an integer from 1 to 10; PA1 p is an integer from 1 to 6; PA1 Y is O or NH.sub.2.sup.+ C1.sup.- ; PA1 z is 0 or 1; PA1 q is about 1 to about 10; PA1 X is a ligand; and, PA1 A is a Michael Addition Adduct. In a preferred embodiment, the ligand is an immunoglobulin, preferably a chimeric antibody or fragment thereof. Also provided are formulations comprising as an active ingredient a compound of Formula (I), intermediates useful for preparing the compounds of Formula (I), processes for preparing the compounds of Formula (I), and methods for using the compounds of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.