Anthracycline prodrugs, method for preparation as well as their use in selective chemotherapy
US5710135A · kind A · utility
33Cited by
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9Claims
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Assignee
Inventors
Key dates
| Filing date | May 24, 1996 |
| Grant date | Jan 20, 1998 |
| Priority date | — |
| Expiry date | May 24, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Anthracycline derivatives are disclosed which are coupled to an enzymatically cleavable N-phenyl-O-glycosyl carbamate spacer group, which derivatives are represented by the formula ##STR1## as well as the acid addition salts thereof. Further the synthesis of these derivatives and their use, alone or in combination with enzymes or antibody enzyme conjugates are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.