Process for the preparation and separation of diastereomeric salts of folinic acid
US5710271A · kind A · utility
3Cited by
11References
7Claims
0Family size
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Jan 20, 1998 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D475/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine and the subsequent separation of the diasteromeric salts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.