7-methoxymethly-3-methyl-1-(5-oxohexyl)xanthine

US5710272A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Werner Aretz · Königstein, DE
• Harald Furrer · Frankfurt am Main, DE
• Ulrich Gebert · Königstein, DE
• Heinz-Joachim Hinze · Wiesbaden, DE

Key dates

• Filing date: Jun 7, 1995
• Grant date: Jan 20, 1998
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/911
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be convened into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereoselectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.