Preparation of fluconazole and pharmaceutically acceptable salts thereof
US5710280A · kind A · utility
6Cited by
1References
20Claims
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Key dates
| Filing date | Jul 9, 1996 |
| Grant date | Jan 20, 1998 |
| Priority date | — |
| Expiry date | Jul 9, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing fluconazole, including the steps of (1) acylating 1,3-difluorobenzene (DFB) to obtain 2-chloro-2',4'-difluoroacetophenone (CAP); (2) alkylating 4-amino-4H-1,2,4-triazole (4-AT) with CAP to obtain 2-(1H-1,2,4-triazol-1-yl)-2',4'-difluoroacetophenone (TAAP) salt; (3) deaminating TAAP salt to obtain TAAP; and (4) reacting TAAP with 1,2,4-triazole to obtain fluconazole.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.