Receptor of the minor human rhinovirus receptor group
US5712245A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 25, 1995 |
| Grant date | Jan 27, 1998 |
| Priority date | — |
| Expiry date | May 25, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/826
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A substantially pure receptor with binding activity for rhinoviruses of the minor human receptor group is disclosed, which has the following characteristics: PA1 (a) a molecular weight of 120 kD on a polyacrylamide gel in the presence of SDS; PA1 (b) a sedimentation constant, determined by sucrose gradient centrifugation in the presence of detergents, corresponding to about 28.4 S; PA1 (c) is bound by Lens culinaris lectin; PA1 (d) is not bound by heparin-sepharose; PA1 (e) is bound irreversibly to an anion exchanger; PA1 (f) has binding activity which is insensitive to neuraminidase; PA1 (g) consists of sub-units connected by intermolecular disulfide bridges; PA1 (h) shows no binding activity to rhinoviruses in the presence of EDTA; and PA1 (i) has a binding activity to rhinoviruses which is only slightly influenced by iodoacetamide. Methods of providing protection against infection by rhinoviruses of the minor receptor group with the substantially pure receptor of the present invention, are also disclosed. A pharmaceutical composition for use in the treatment of rhinovirus infections is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.