Use of lactoferrin to modulate and/or neutralize heparin activity
US5712247A · kind A · utility
9Cited by
2References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1995 |
| Grant date | Jan 27, 1998 |
| Priority date | — |
| Expiry date | Feb 21, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for modulating, regulating and/or neutralizing heparin-dependent anticoagulant reactions by administration of lactoferrrin or polypetide fragments thereof. Said method may be used to correct the "heparin-induced" prolongation of blood coagulation and other coagulapathies in cardiopulmonary bypass, cardiac catheterization and hemodialysis patients. Said method may further be used to treat disorders and diseases related to unregulated or unmodulated heparin activity. Said method of treatment is comprised of administration of lactoferrin or fragments thereof comprised of the heparin binding domain(s) of lactoferrin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.