Quaternary basic amides, method of preparing them and pharmaceutical compositions in which they are present
US5712288A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 18, 1996 |
| Grant date | Jan 27, 1998 |
| Priority date | — |
| Expiry date | Oct 18, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D453/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to quaternary basic amides of the formula ##STR1## in which Ar is an optionally substituted mono-, di- or tri-cyclic aromatic or heteroaromatic group; PA1 T is a direct bond, a hydroxymethylene group, an alkoxymethylene group in which the alkoxy group is C.sub.1 -C.sub.4, or a C.sub.1 -C.sub.5 -alkylene group; PA1 Ar' is an unsubstituted or mono- or poly-substituted phenyl, a thienyl, a benzothienyl, a naphthyl or an indolyl; PA1 R is hydrogen or a C.sub.1 -C.sub.4 -alkyl, or a C.sub.1 -C.sub.4 -.omega.-alkoxy(C.sub.2 -C.sub.4)alkyl, or a C.sub.2 -C.sub.4 -.omega.-alkanoyloxy (C.sub.1 -C.sub.4)alkyl; PA1 Q is hydrogen; PA1 or else Q and R together form a 1,2-ethylene, 1,3-propylene or 1,4-butylene group; PA1 Am.sup..sym. is the radical ##STR2## in which X.sub.1, X.sub.2 and X.sub.3, together with the nitrogen atom to which they are bonded, form a 1-azoniabicyclo2.2.2!octane optionally substituted by a phenyl or benzyl group; and PA1 A.sup..crclbar. is a pharmaceutically acceptable anion. These compounds are useful for the preparation of drugs intended for the treatment of pathological conditions involving the tachykinin system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.