Hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
US5712300A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 4, 1997 |
| Grant date | Jan 27, 1998 |
| Priority date | — |
| Expiry date | Mar 4, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides novel hydroxamic acid derivatives represented by the compound of formula I ##STR1## or pharmaceutical acceptable salts thereof, wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, including collagenase, stromelysin, and gelatinase, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthrits, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.