Process for the solubilization of peptides and process for peptide synthesis
US5712367A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 1994 |
| Grant date | Jan 27, 1998 |
| Priority date | — |
| Expiry date | Oct 25, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K17/06
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process is disclosed for making peptides soluble in a water-immiscible organic solvent, comprising linking a lipophilic group with an amide or ester bond to the terminal carboxyl group of said peptide; when the lipophilic group is linked to L-serine, a molecule is obtained with a solubility in water at 25.degree. C. of less than 30 g/liter. This lipophilic group is non-polymeric and chemically defined. A process is also disclosed for the synthesis of peptides, optionally protected, in a liquid medium, wherein the starting material is an amino acid or peptide made soluble in an organic medium by a lipophilic group A--L linked to the carboxyl function of the starting amino acid or peptide, and are added to amino acids or peptides to be condensed which are activated on their acid function and protected on their amine function and are optionally protected on their side chain. The peptides resulting from the synthesis are used, where appropriate, for the synthesis of medicinal products, vaccines or agri-foodstuff or plant-protection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.