Method and compositions for increasing the serum half-life of pharmacologically active agents by binding to transthyretin-selective ligands
US5714142A · kind A · utility
50Cited by
2References
27Claims
0Family size
Inventors
Key dates
| Filing date | Jun 13, 1996 |
| Grant date | Feb 3, 1998 |
| Priority date | — |
| Expiry date | Jun 13, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/54
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for increasing the serum half-life of a pharmacologically active agent. The novel compositions are covalent conjugates of the selected pharmacologically active agent and a transthyretin-binding ligand such as tetraiiodothyroacetic acid, 2,4,6-triiodophenol, flufenamic acid, or the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.