Bioactive and/or targeted dendrimer conjugates

US5714166A · kind A · utility

Assignees

• THE DOW CHEMICAL COMPANY · US
• Dendritech Inc. · US
• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Donald A. Tomalia · Midland, US
• James R. Baker, JR. · Ann Arbor, US
• Roberta C. Cheng · Midland, US
• Anna U. Bielinska · Ypsilanti, US
• Michael J. Fazio · Midland, US
• David M. Hedstrand · Midland, US
• Jennifer Ann JOHNSON · Livonia, US
• Donald A. Kaplan · Cincinnati, US
• Scott L. Klakamp · Russell, US
• William J. Kruper, Jr. · Sanford, US
• Jolanta F. Kukowska-Latallo · Ann Arbor, US
• Bartley D. Maxon · St. Louis, US
• Lars T. Piehler · Midland, US
• Ian A. Tomlinson · Midland, US
• Larry R. Wilson · Beaverton, US
• Rui Yin · Newark, US
• Herbert M. Brothers, II · Midland, US

Key dates

• Filing date: Mar 7, 1995
• Grant date: Feb 3, 1998
• Expiry date: Mar 7, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S424/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present then the carried material may be a bioactive agent. Preferred dendritic polymers are dense star polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.