Active agent transport systems
US5714167A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 1994 |
| Grant date | Feb 3, 1998 |
| Priority date | — |
| Expiry date | Oct 25, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: PA1 (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; PA1 (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and PA1 (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for prep…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.