Modified fungal cells and method for producing recombinant products

US5714377A · kind A · utility

Assignee

• RHONE-POULENC RORER S.A. · FR

Inventors

• Widmar Tanner · Regensburg, DE
• Sabine Strahl-Bolsinger · Regensburg, DE
• Reinhard Fleer · Les Ulis, FR
• Alain Fournier · ᐙᔂᓂᐲ Waswanipi, CA

Key dates

• Filing date: Apr 18, 1995
• Grant date: Feb 3, 1998
• Expiry date: Apr 18, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/81
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This invention relates to improved fungal cells and methods for producing recombinant products of improved quality and in high yields. More specifically, the present invention relates to fungal cells carrying specific modifications within their DNA sequences which cause them to exhibit at least a reduced capacity for O-glycosylating homologous and/or heterologous proteins, and the use of these cells as host cells to produce high yields of recombinant products.