Tetrahydrofuran antifungals

US5714490A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Anil K. Saksena · Upper Montclair, US
• Viyyoor M. Girijavallabhan · Parsippany, US
• Raymond G. Lovey · West Caldwell, US
• Russell E. Pike · Stanhope, US
• Haiyan Wang · Cranbury, US
• Yi Liu · San Diego, US
• Ashit K. Ganguly · Upper Montclair, US
• Frank Bennett · Piscataway, US

Key dates

• Filing date: Jun 2, 1995
• Grant date: Feb 3, 1998
• Expiry date: Jun 2, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65586
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two amino acid ester groups (e.g., an amino acid ester group convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.