Xanthines in the 7th position with a benzyl acetic acid moiety

US5714494A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Richard Connell · Trumbull, US
• Siegfried Goldmann · Wuppertal, DE
• Ulrich Muller · Wuppertal, DE
• Stefan Lohmer · Milano, IT
• Hilmar Bischoff · Wuppertal, DE
• Dirk Denzer · Wuppertal, DE
• Rudi Grutzmann · Solingen, DE
• Stefan Wohlfeil · Hilden, DE

Key dates

• Filing date: Sep 18, 1996
• Grant date: Feb 3, 1998
• Expiry date: Sep 18, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted xanthines of formula ##STR1## in which A represents a radical of the formula ##STR2## in which R.sup.3, R.sup.4, R.sup.6 and R.sup.7 denote hydrogen, cycloalkyl, aryl having 6 to 10 carbon atoms, or denote straight-chain of branched alkyl or alkenyl, each of which is optionally substituted; T, V, X and Y are identical or different and denote an oxygen or sulphur atom; R.sup.5 and R.sup.8 are identical or different and denote hydrogen, halogen, cycloalkyl having 3 to 8 carbon atoms or straight-chain or branched alkyl or alkenyl in each case having up to 8 carbon atoms, optionally substituted or R.sup.5 and R.sup.8 denote aryl having 6 to 10 carbon atoms or a 5- to 7-membered aromatic, optionally benzo-fused heterocycle having up to 3 heteroatoms S, N and/or O, each of which is optionally substituted; L represents an oxygen or sulphur atom; R.sup.2 represents mercapto, hydroxyl, straight-chain or branched alkoxy having up to 8 carbon atoms or the group of the formula ##STR3## in which R.sup.13 denotes hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms; R.sup.14 denotes hydrogen, phenyl or a 5- to 6-membered aromatic heterocycle having up to 3 heteroa…