Inhibitors of bacterial sialidase and methods of making and using the same
US5714509A · kind A · utility
18Cited by
1References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 3, 1995 |
| Grant date | Feb 3, 1998 |
| Priority date | — |
| Expiry date | May 3, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/66
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A sialidase inhibitor of the shown formula I: ##STR1## where dashed lines d.sub.1 and d.sub.2, X.sub.1, R.sub.1, R.sub.2, R.sub.6, R.sub.3, R.sub.4 and R.sub.5 are as described in the specification; or an analog, pharmaceutically acceptable salt, or derivative of the inhibitor, with the proviso that the inhibitor is not HNBA GBA or Neu5Ac2en. The inhibitor in a composition with a pharmaceutically acceptable carrier. Methods of making a pharmaceutical composition of an acceptable carrier and the inhibitor. Methods of inhibiting sialidase and methods of treating and preventing bacterial or trypanosomal infection using the inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.