Contrast medium for magnetic resonance imaging using physiologically tolerable manganese compound

US5716598A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Klaes Golman · Hørsholm, DK
• Goran Pettersson · Hjärup, SE
• Arne Berg · Sandvika, NO
• Jo Klaveness · Oslo, NO
• Pal Rongved · Oslo, NO
• Peter Leander · Lund, SE

Key dates

• Filing date: Jun 5, 1995
• Grant date: Feb 10, 1998
• Expiry date: Jun 5, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided a contrast medium composition for magnetic resonance imaging comprising a physiologically tolerable manganese compound, a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group, or salt thereof and a physiologically tolerable carrier or excipient, having a manganese concentration of at least 0.3 mM or being in a dosage unit form containing at least 300 .mu.mol manganese. Such compositions are particularly suitable for imaging of the liver.