Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
US5716614A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1994 |
| Grant date | Feb 10, 1998 |
| Priority date | — |
| Expiry date | Aug 5, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6415
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is disclosed for delivering biologically active agents to a mammalian brain by administering a complex of the biologically active agent with a polycationic carrier coupled to 2-20 eicosapentaenoic acid or docosahexaenoic acid moieties and additional eicosapentaenoic acid or docosahexaenoic acid moieties. The polycationic carrier is poly-lysine, poly-arginine or poly-ornithine of 5-50 amino acid residues. The addition of a targeting moiety selected from tetanus toxin C fragrant, .alpha.-bungarotoxin and nerve growth factor to the complex facilitates delivery of the biologically active agent to glial tissue, or to cortical, cholinergic and adrenergic neurons.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.