Composition for applying active substances to or through the skin

US5716638A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventor

• Elka Touitou · Hod HaSharon, IL

Key dates

• Filing date: Nov 27, 1995
• Grant date: Feb 10, 1998
• Expiry date: Nov 27, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q19/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A cosmetic or medical composition for topical application to the skin. It results in the transdermal passage of an active ingredient, or in the introduction of such agent into the skin. The essential components of such compositions are phospholipids, an aliphatic alcohol of three or four carbon atoms or a combination of these alcohols, water and a compatible active ingredient, optionally with propylene glycol. Compositions advantageously comprise from 0.5% to 10% phospholipids, from 5% to 35% of a C.sub.3 - or C.sub.4 -alcohol, 15 to 30% ethanol, which contain together at least 20% but not more than 40 wt. % of ethanol and the C.sub.3 -alcohol; up to 20 wt. % propylene glycol, at least 20% water and at least one active ingredient. The compositions are suitable for the topical application of a wide variety of cosmetic and pharmaceutically active compounds. Phospholipids of choice are phosphatidylcholine, (P C), hydrogenated P C, phosphatidic acid (P A), phosphatidylserine (P S), phosphatidylethanolamine (P E), phosphatidylglycerol (P P G) and phosphatidylinositol (P I).