Celiac antigen
US5716794A · kind A · utility
59Cited by
3References
1Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 29, 1996 |
| Grant date | Feb 10, 1998 |
| Priority date | — |
| Expiry date | Mar 29, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/38
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In this invention a novel antigen is provided for screening patients suspected of having celiac disease. The antigen is prepared by starting with human placenta tissue which is perfused with a herpes and collagenase buffer to obtain a signle cell suspension. This suspension is enriched to obtain an enriched protein portion and then separated out to obtain an embryonic celiac antigen (ECA). This ECA is used with serum from patients to effect binding of ECA with IgA in the serum while applying a human IgA antibody to the serum. The results are then read on a spectrophotometer to confirm or negate the presence of celiac disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.