Process for the resolution of ethyl 4,4,4-trifluoro-3(R)-hydroxybutanoate using lipase from candida

US5716841A · kind A · utility

Assignee

• Synthelabo · FR

Inventors

• Arlette Tixidre · Gif-sur-Yvette, FR
• Lydia Zard · Gif-sur-Yvette, FR
• Guy Rossey · Voisins-le-Bretonneux, FR
• Andre Bourbon · Mantes-la-Ville, FR

Key dates

• Filing date: Apr 5, 1996
• Grant date: Feb 10, 1998
• Expiry date: Apr 5, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/005
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for the preparation of ethyl 4,4,4-trifluoro-3(R)-hydroxybutanoate, wherein the ester functional group of the (S) enantiomer of ethyl (.+-.)-4,4,4-trifluoro-3-hydroxybutanoate which comprises (R) and (S) is selectively hydrolysed in aqueous medium, by means of a lipase, and the non-hydrolysed (R) enantiomer is then extracted and used in the preparation of 4,4,4-trifluoro-1,3(R)-butanediol.