Patent · US Expired

Insulin analogs having a modified B-chain

US5716927A · kind A · utility

33Cited by

4References

17Claims

0Family size

Assignee

Novo Nordisk A/S · DK

Inventors

Per Balschmidt · Humlebæk, DK
Jens J. V. Brange · Klampenborg, DK

Key dates

Filing date	Sep 21, 1995
Grant date	Feb 10, 1998
Priority date	—
Expiry date	Sep 21, 2015

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Human insulin analogues having a positively charged amino acid residue, i.e. Lys or Arg, in position B28, further being modified in the C-terminal end of the B-chain from Phe.sup.B24 to the C-terminal amino acid residue and wherein A18, A21 and/or B3 is different from Asn as well as insulin preparations containing the human insulin analogues are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.