Use of coumarins and carbostyrils as PLA.sub.2 inhibitors, new coumarins and carbostyrils, processes for the production thereof and pharmaceutical agents

US5716983A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Walter-Gunar Friebe · Mannheim, DE
• Wolfgang Schaefer · Sankt Augustin, DE
• Werner Scheuer · Penzberg, DE
• Ulrich Tibes · Starnberg, DE

Key dates

• Filing date: Mar 14, 1996
• Grant date: Feb 10, 1998
• Expiry date: Mar 14, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Use of compounds of formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, Y and Z have the meanings stated in the claims, tautomers thereof as well as their salts with non-toxic acids or bases for the production of pharmaceutical agents having an inhibitory action on PLA.sub.2 in addition to compounds of formula I in which X does not denote a valency and processes for the production thereof.