Peptide inhibitors of tax-dependent transcription
US5717058A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 18, 1994 |
| Grant date | Feb 10, 1998 |
| Priority date | — |
| Expiry date | Feb 18, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/14022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to regulators of cellular gene transcription, particularly inhibitors of cellular gene transactivating factors and in particular to inhibition of gene transcription in a viral host cell that is subject to regulation by proteins or factors that originate from a virus as well as conjugates or fusion products of the inhibitors and internalization molecules, pharmaceutical compositions that can be used to alleviate or prevent the manifestation of disease states that are the result of unregulated DNA transcription as a result of transactivation, methods of treating diseases that are caused or exacerbated by the presence of transactivating factors, and regulated gene therapy to achieve long term drug delivery of the inhibitors of the present invention. This invention can be applied both to cells with genetic abnormalities or to cells infected with a virus. Preferably, at least one protein of the protein-protein interactions is a transactivating factor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.