Process for preparing codon amidites
US5717085A · kind A · utility
25Cited by
2References
6Claims
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Key dates
| Filing date | Nov 23, 1994 |
| Grant date | Feb 10, 1998 |
| Priority date | — |
| Expiry date | Nov 23, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing a trinucleotide phosphoramidite comprising reacting a 3',5'-dihydroxy dinucleoside with a nucleoside 5'-phosphoramidite; oxidizing this trinucleotide phosphite to produce the 3'-hydroxyl trinucleotide; and finally converting the 3'-hydroxy trinucleotide to the 3'-phosphoramidite derivative. Such trinucleotide phosphoramidites provide a convenient route for synthesizing oligonucleotides with randomized codons at specified positions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.