Process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol
US5717096A · kind A · utility
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11Claims
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Key dates
| Filing date | Mar 25, 1997 |
| Grant date | Feb 10, 1998 |
| Priority date | — |
| Expiry date | Mar 25, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/52
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol of the general formula: ##STR1## in which R is a C.sub.1 -C.sub.8 -alkyl group. In the process, cyanamide is reacted with the appropriate alcohol in the presence of hydrogen chloride to give the corresponding alkoxyisourea hydrochloride, which is then converted with ethyl trifluoroacetoacetate in the presence of an alkali metal hydroxide, which is in water, to the end product of the formula I.
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