Method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants

US5718726A · kind A · utility

Assignee

• BIOTRONIK MESS-UND THERAPIEGERATE · DE

Inventors

• Michael Amon · Dormitz, DE
• Armin Bolz · Buckenhof, DE
• Dirk Müssig · West Linn, US

Key dates

• Filing date: Sep 11, 1996
• Grant date: Feb 17, 1998
• Expiry date: Sep 11, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F2310/00742
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants such as cardiac valves or alloplastic vessel wall supports, comprising the following steps: PA1 activation of the inorganic substrate surface by etching, PA1 attachment, by exposure to ultraviolet light, of a photoactive benzophenone compound with an amino protective group as a spacer to the activated substrate surface, PA1 splitting off of the amino protective group by the aid of a non-aqueous piperidine solution, and PA1 covalent peptide-bonding of heparin to the free and reactive amino groups of the substrate surface by an aqueous heparin solution acting on the amino groups.