Muscarine agonists

US5718912A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Wayne J. Thomspon · Lansdale, US
• Pierre Mallorga · Lansdale, US
• Richard W. Ransom · Doylestown, US
• Ian M. Bell · Harleysville, US
• Michael F. Sugrue · Blue Bell, US
• Peter M. Munson · Harleysville, US

Key dates

• Filing date: Oct 28, 1996
• Grant date: Feb 17, 1998
• Expiry date: Oct 28, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention is concerned with novel 1-cycloalkylpioeridin-4-yl!-2H benzimidazolones, their compositions and method of use. The novel compounds are selective muscarinic agonists of the m2 subtype with low activity at the m3 subtype. The compounds are effective for the treatment of glaucoma with fewer side effects than the pilocarpine therapy.