Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates

US5719164A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Klaus Weidmann · Kronberg, DE
• Karl-Heinz Baringhaus · Blieskastel, DE
• Georg Tschank · Frankfurt am Main, DE
• Martin Bickel · Frankfurt am Main, DE

Key dates

• Filing date: Jul 3, 1996
• Grant date: Feb 17, 1998
• Expiry date: Jul 3, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/48
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted quinoline-2-carboxylic acid amides of the formula I ##STR1## their preparation and their use, and intermediates which are formed in the preparation of the compounds of the formula I. The compounds according to the invention are used as inhibitors of prolyl 4-hydroxylase and as pharmaceuticals (medicaments) for treatment of fibrotic diseases.