Substituted benzoylguanidines, their use as a medicament or diagnostic, and medicament containing them

US5719169A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinz-Werner Kleemann · Bischofsheim, DE
• Hans-Jochen Lang · Hofheim, DE
• Jan-Robert Schwark · Frankfurt am Main, DE
• Andreas Weichert · Egelsbach, DE
• Wolfgang Scholz · Beverly, US
• Udo Albus · Florstadt, DE

Key dates

• Filing date: Jul 3, 1996
• Grant date: Feb 17, 1998
• Expiry date: Jul 3, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/64
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to benzoylguanidines of the formula I: ##STR1## to pharmaceutically acceptable salts of these compounds and to a process for preparing compounds of the formula I, which comprise reacting a compound of the formula II ##STR2## with guanidine. The compounds of the invention are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for the prophylaxis and treatment of infarction and for the treatment of angina pectoris.