Benzocycloalkylazolethione derivatives and processes for preparing the same
US5719280A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 7, 1997 |
| Grant date | Feb 17, 1998 |
| Priority date | — |
| Expiry date | Apr 7, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/582
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel benzocycloalkylazolethione compounds which are dopamine .beta.-hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-1,2,4!triazol-4-yl and 5-thioxo-4,5-dihydro-1H-1,2,4!triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.