Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use

US5720950A · kind A · utility

Assignee

• University of Medicine and Dentistry of New Jersey · US

Inventors

• George J. Poiani · Jamesburg, US
• David J. Riley · New Brunswick, US
• Wei-Chi Liao · Douliu, TW
• Joachim Kahn · Ehringshausen, DE
• Keria Fiorella Gean · Highland Park, US

Key dates

• Filing date: Jun 15, 1994
• Grant date: Feb 24, 1998
• Expiry date: Jun 15, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G81/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collagen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.