2,8-disubstituted quinazolinones

US5721238A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Fred R. Heiker · Wuppertal, DE
• Ulrich Niewohner · Wermelskirchen, DE
• Wolfgang Hartwig · Wuppertal, DE
• Helmuth Schutz · Regensburg, DE
• Erwin Bischoff · Wuppertal, DE
• Elisabeth Perzborn · Wuppertal, DE
• Matthias Schramm · Cologne, DE

Key dates

• Filing date: Jan 11, 1996
• Grant date: Feb 24, 1998
• Expiry date: Jan 11, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/91
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

2,8-Disubstituted quinazolinones are prepared by first subjecting the quinazolinone basic skeleton to condensation by customary reactions and then introducing the desired substituents into the 8-position. The compounds are suitable as active compounds in medicaments, in particular for the treatment of inflammations, thromboembolic diseases and cardiovascular diseases.