Method of using 2-formylpyridine thiosemicarbazone compounds
US5721259A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 22, 1996 |
| Grant date | Feb 24, 1998 |
| Priority date | — |
| Expiry date | Aug 22, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/76
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of treatment of tumors is provided based upon a compound of the formula ##STR1## wherein one of R.sup.1 is NHR.sup.4 or NR.sup.4 R.sup.5 or R.sup.3 is NHR.sup.4, NR.sub.4 R.sup.5 or OH, and the other is hydrogen; PA1 R.sup.2 is hydrogen or C.sub.1-4 lower alkyl; PA1 R.sup.4 is hydrogen, hydroxyl or C.sub.1-4 lower alkyl; and PA1 R.sup.5 is C.sub.1-4 lower alkyl; or a pharmaceutically acceptable salt or hydrate thereof. In a further aspect there is provided a method for the treatment of a tumor in a mammal which comprises administration of a compound which is 3- or 5-hydroxy-4-methyl-2-formylpyridine thiosemicarbazone to said mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.