Process for producing ecteinascidin compounds
US5721362A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 18, 1996 |
| Grant date | Feb 24, 1998 |
| Priority date | — |
| Expiry date | Sep 18, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to a synthetic process for the formation of ecteinascidin compounds and related structures, such as the saframycins. In one particularly preferred embodiment, the present invention provides a synthetic route for the formation of ecteinascidin 743 (1), ##STR1## an exceedingly potent and rare marine-derived antitumor agent which is slated for clinical trials. The process of this invention is enantio- and stereocontrolled, convergent and short. Also disclosed are novel process intermediates, useful not only in the total synthesis of ecteinascidin 743, but also other known ecteinascidin compounds, including derivatives and analogs thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.