"Cytotoxic T-cell lymphocyte (""CTL"") activity regulation by class I MHC peptides"

US5723128A · kind A · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Carol Clayberger · Stanford, US
• Alan M. Krensky · Stanford, US
• Peter Parham · Stanford, US

Key dates

• Filing date: Apr 5, 1994
• Grant date: Mar 3, 1998
• Expiry date: Apr 5, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/868
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fragments from the polymorphic domains of Class I HLA antigen domains are used to modulate T-cell activity. The peptides are from the .alpha.1- or .alpha.2 domains, particularly of the HLA-A, and B antigens. The peptides may be conjugated to other compounds to be used in diagnosis and therapy. The peptides may block lysis, CTL proliferation or have other regulating effects.