Transdermal absorption preparation
US5723145A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jul 22, 1997 |
| Grant date | Mar 3, 1998 |
| Priority date | — |
| Expiry date | Jul 22, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7084
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a transdermal absorption preparation whereby a drug, which takes effect with a small amount, and is liable to be decomposed, solid at ordinary temperatures, water-soluble and less absorbable into the skin, can be stored stably for a long period of time and, can be transdermally administered at a high releasing ratio and yet releasing slowly, when applied to the skin. The constitution of the present invention is as follows: a transdermal absorption preparation which comprises a drug-storing layer containing a drug and having a drug-releasing face coated with a drug-releasing controlling membrane, wherein said drug-storing layer comprises as a base a heat-sensitive segmented polyurethane represented by the general formula: EQU R--A--(U)--F--(U)--B--R' wherein A and B each represents a polymer of ethylene oxide, propylene oxide, tetramethylene oxide or 1,2-butylene oxide, or a random or block copolymer thereof, R and R' each represents a terminal H, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7 or C.sub.4 H.sub.9, A=B or A.noteq.B, R=R' or R.noteq.R', F represents a constituting structure which is a moiety of a diisocyanate compound excluding two isocyanate…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.