Methods for screening compounds for estrogenic activity
US5723291A · kind A · utility
10Cited by
1References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 27, 1995 |
| Grant date | Mar 3, 1998 |
| Priority date | — |
| Expiry date | Mar 27, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters having an AP1 site linked to a reporter gene. Compounds capable of inducing or blocking expression of the reporter gene can thus be identified. The compounds may be further tested for the ability to modulate the standard estrogen response, as well.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.