Method to screen compounds that affect GAPDH binding to polyglutamine
US5723301A · kind A · utility
8Cited by
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Key dates
| Filing date | Nov 3, 1995 |
| Grant date | Mar 3, 1998 |
| Priority date | — |
| Expiry date | Nov 3, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6896
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
GAPDH binds to expanded polyglutamine regions which are found in proteins encoded by genes with CAG repeat domains, which genes cause inherited neurodegenerative disorders and are associated with certain psychiatric disorders. Therapeutic methods are based on inhibiting the binding of GAPDH to expanded polyglutamine regions. A method of screening compounds for the ability to inhibit binding of GAPDH to polyglutamine regions is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.