Position-addressable polynucleotide arrays
US5723320A · kind A · utility
116Cited by
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13Claims
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Inventor
Key dates
| Filing date | Aug 29, 1995 |
| Grant date | Mar 3, 1998 |
| Priority date | — |
| Expiry date | Aug 29, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B60/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for producing a high-density, position-addressable gene array is disclosed. The method includes contacting an array of different-sequence oligonucleotides having a unique, known combinatorial sequence associated with each position in the array with a set of extended gene probe templates which are complementary to the oligonucleotides at one of the template end regions. After hybridization, the oligonucleotides in the array are extended by strand-directed polymerization to form the probe array. Also disclosed is a probe array device formed by the method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.