DNA encoding retinoid receptor X (RXR) alpha and gamma; corresponding vectors and host cells
US5723329A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 8, 1994 |
| Grant date | Mar 3, 1998 |
| Priority date | — |
| Expiry date | Nov 8, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/75
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to novel receptor polypeptides, which, upon interaction with certain ligands, or activation by certain compounds, modulate transcription of certain genes by binding to cognate response elements associated with promoters of such genes. The novel receptors of the invention modulate transcription in the presence of retinoid compounds. The receptors of the present invention differ significantly from known retinoic acid receptors, in protein primary sequence and in responsiveness to exposure to various retinoids. The invention provides DNAs encoding the novel receptors, expression vectors for expression of the receptors, cells transformed with such expression vectors, cells co-transformed with such expression vectors and with reporter vectors to monitor modulation of transcription by the receptors, and methods of using such co-transformed cells in screening for compounds which are capable, directly or indirectly, of activating the receptors. The invention also provides nucleic acid probes for identifying DNAs which encode additional retinoid receptors of the same class as the novel receptors disclosed herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.