Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide

US5723615A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Kai Rossen · Hanau, DE
• Steven A. Weissman · Little Falls, US
• Jess Sager · Bound Brook, US
• David Askin · Hackettstown, US
• Paul J. Reider · Westfield, US
• Ralph P. Volante · Rahway, US

Key dates

• Filing date: Jun 18, 1996
• Grant date: Mar 3, 1998
• Expiry date: Jun 18, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butyl-carboxamide, an intermediate for an HIV protease inhibitor.