Radiolabeled D4 receptor ligands
US5725838A · kind A · utility
3Cited by
9References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 12, 1996 |
| Grant date | Mar 10, 1998 |
| Priority date | — |
| Expiry date | Nov 12, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/2208
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Herein described are radiolabeled compounds and their precursors useful to image D4 receptors in vivo, of the formula: ##STR1## wherein R is selected from iodo, tri(loweralkyl)tin and a radioisotopically labeled iodide and R.sup.1 is selected from H and alkoxycarbonyl, with the proviso that R is not iodo when R.sup.1 is H. The radiopharmaceutical compounds are useful particularly to image localization of D4 receptor in the human brain, and can therefore aid in the diagnosis of schizophrenia and other medical conditions in which the D4 receptor is implicated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.