Method for reducing the risk of developing diabetes
US5725860A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 7, 1996 |
| Grant date | Mar 10, 1998 |
| Priority date | — |
| Expiry date | Aug 7, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55594
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The incidence of the autoimmune disease, diabetes mellitus, is well controlled in the nude-obese-diabetic (NOD) mouse model using injections of the A chain fragment (or parts thereof) of the insulin molecule as an antigen in combination with killed cells (or parts thereof) of Haemophilus pertussis, acting as an adjuvant. This leads to the convenient prevention of diabetes in humans using the common "Triple vaccine" (DPT) diphtheria/whooping cough/tetanus vaccine (or versions thereof) in combination with A chain fragment of insulin. This mixture can be given to an at-risk population in which diabetes is expected to occur at an abnormally high rate, or it can be given to the entire population.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.